You really need to treat the entire apartment or room. The bed bugs will hide all around the room, including the crib frame. For now, I'd do the following:
1. Treat the entire mattress and crib with a mattress safe bed bug spray.
2. Cover the mattress with a bed bug cover after the spray dries
3. Treat the crib with the mattress spray and a residual spray
4. Keep the crib at least 6 inches from every wall and furniture
5. Put inexpensive bed bug traps under each crib leg (see climbup below)
6. Wrap double sided tape on each bed leg
Here are the detailed instructions for killing bed bugs in a home:
The best approach, if you can afford it, is to call an exterminator. A recent poll showed that exterminators consider this the toughest insect to kill, often requiring 2 to 3 treatments. I usually recommend starting with a call to Service Magic (1.877.233.1145) since they pre-screen members to make sure they are licensed and insured. They provide up to 3 free quotes, an important factor when treatment costs and methods used vary. Figure a home will cost $1000 to 1500 to treat all in.
Due to the high cost, many home owners decide to purchase a kit. I included a good resource for kits below as well as the general instructions. Be sure to buy a kit, or at least the combination of products that are in the kit. Basically, you'll need a few methods to reduce the size of the bed bug population (spray, steam, vacuuming), and products to interrupt the bed bug life cycle and kill any bed bugs and eggs you might have missed (sprays, bed bug dust).
Here are the basic steps for a do it yourself bed bug treatment:
1. Dispose of all clutter.in sealed plastic bags.
2. Wash all linen, sheets, blankets etc in hot water followed by 20 to 30 minutes in the dryer.
3. Vacuum the mattress, box spring, bed frame and floor. Go around the baseboard and cracks with a vacuum crevice tool. Follow this with a hand steamer if you have one.
4. Use a mattress safe knock down spray to kill bed bugs and bed bug eggs. Be sure to treat the mattress, box spring, bed frame, end tables and other areas near and around the bed. Spray outside and inside any furniture.
5. Use a residual spray for longer lasting protection. Spray baseboards, in cracks and crevices. Be sure to spray everything within 10 feet of the bed. Look behind mattress labels and particularly inside the box spring and behind and plastic corner guards.
6. Encase the mattress and box spring after the spray dries with bed bug covers
7. Steam clean carpets. Add a disinfectant to the cleaning fluid (test to make sure it doesn't harm carpet)
8. Place inexpensive bed bug traps (climbup) under bed legs, if the traps remain empty for 2 to 3 weeks, you are bed bug free.
9. For added protection, consider adding a thin layer of bed bug dust (also called fossil dust or diatomaceous earth) around the mattress seams, and in cracks, under baseboards, inside the box spring. The dust attaches to the bed bugs, causing death. Not a perfect solution, but again, the goal is to reduce the size of the population with each treatment, until the bed bugs are gone.
If you can't afford treatment, contact your local department of health to see if they can help. Also, you can call exterminators such as service magic (1.877.233.1145) and negotiate costs. Tell them what you can spend and see if they can help.